United will be without Edinson Cavani, who is banned, with Victor Lindelof also an injury doubt, with Eric Bailly once again expected to partner Harry Maguire in defence.
Having been knocked out of three cup competitions at the semi-final stage last season, Ole Gunnar Solskjaer's side will be hoping to progress and bag some silverware in this campaign.City will be missing a number of players against United due to coronavirus, with Gabriel Jesus, Eric Garcia, Kyle Walker, Ederson, Ferran Torres and Tommy Doyle all self-isolating.
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