Officers stopped a a Volkswagen Sharan and a Mercedes R350 around 2.45pm on Sunday afternoon as part of an intelligence led operation.
The search, on the M74 northbound near to junctions 13 and 8, led to £106,000 of Class-B drugs being recovered. The drivers of each vehicle, along with a passenger from the Mercedes, were arrested at the scene as police continued to search the cars.
One man, aged 46-year-old, has been charged in connection with drugs offences and is due to appear in court at a later date.
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