Manchester United debut against former club Paris St Germain after the Premier League giants confirmed quarantine regulations mean the Uruguayan is unavailable for the weekend trip to Newcastle.
Following his exit from PSG in June, Cavani joined United on a free transfer on deadline day and went into self-isolation for a 14-day period after arriving from France on October 4.
It had been anticipated that coronavirus guidelines would lead to Cavani missing out at St James' Park on Saturday and United revealed the 33-year-old's earliest availability is the Champions League clash at PSG next Tuesday.
However, given Cavani is unable to train with his new team-mates until the day before the visit to the French capital, his readiness for the.
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