played to the hilt by Demi Moore (what’s wrong with her?!), is an Oscar winner turned fading fitness guru a la Suzanne Somers whose luxurious Hollywood home is plastered with giant portraits of her in her prime. After Elisabeth is abruptly fired from her TV job, “Sparkle With Elizabeth,” the gutted actress learns of an underground drug called the Substance that promises to create a younger, sexier doppelgänger of a person.