EastEnders actress, 49, took to Instagram on Friday to share the sad news and poignantly wrote: 'Cannot cope with losing you, not now. . . ' alongside a gallery of images with her pooch.
Last month Samantha announced that she she'd 'started her own battle' with the disease as she paid tribute to Olivia Newton-John, who died aged 73 after long fight with cancer.
In the post about the death of the German shepherd greyhound mix, Samantha shared an array of sweet snaps with her pet as she cuddled and doted on him.
There was also a selection of close up pictures of Lola in sweet outfits and sleeping as well as posing with her other pets.
Read more on msn.com