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Prince Frederik of Luxembourg’s heroic final act revealed before death at 22
beloved royal died on March 1 from POLG Mitochondrial disease — a rare genetic disorder that affects approximately one in 5,000 people.The genetic disorder affects multiple organ systems and the mitochondria, the energy-producing parts of cells.Frederik was diagnosed with the disease at the age of 14 after enduring unexplained symptoms for years.In 2022, Frederik founded The POLG Foundation, an organization that researches the disease and searches for a cure.Despite his short lifespan, the prince managed to create an inspiring legacy through his foundation, which his father vows to continue in his son’s name.“He had barely been able to speak for several days, so the clarity of these words was as surprising as the weight of the moment was profound,” Prince Robert, 56, said of his late son.“Frederik knows that he is my Superhero, as he is to all of our family, and to so very many good friends and now in great part thanks to his POLG Foundation, to so very many people the world over.”Despite his health battle, Frederik worked tirelessly to raise awareness about the illness in a desperate bid to help others.He then joined forces with designer Donna Karan to develop the MITO clothing line, selling items through his POLG Foundation to raise awareness and funds.In addition, Frederik participated in medical trials which helped to develop cell lines for research across Switzerland, the US and Europe.His work laid the foundation for The POLG Toolbox, a crucial resource for scientists, his proud father said.“The POLG Foundation, in only three short years, has accomplished so very much, including funding four major research projects, totaling over $3.6 million,” said Robert, the first cousin of Grand Duke Henri of

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