Ralf Rangnick has already confirmed that Donny van de Beek, Nemanja Matic and Dean Henderson will start against Young Boys in what could be the first of several more changes.
United will bring their Champions League group stage campaign to a close on Wednesday with the visit of the Swiss to Old Trafford, safe in the knowledge that they have already secured top spot in Group F.
As a result, the match is a complete dead rubber and affords new interim boss Rangnick the chance to get a good look at the members of his team who didn't start in his first game in charge against Crystal Palace on Sunday.
The German has admitted he doesn't know quite how many changes he will make as injuries have limited his options and he hopes to continue
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