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United will play the first leg on April 8th and the second on April 15th, visiting the La Liga side first before hosting them at Old Trafford.
Ole Gunnar Solskjaer's side booked their place in the last eight of UEFA's secondary competition with a 2-1 aggregate victory over AC Milan.
Paul Pogba scored the only goal of the second leg at the San Siro to help United knock out the Italian giants. United beat Real Sociedad 4-0 over two legs in the last 32 after dropping into the Europa League after they finished third in their Champions League group.
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