The Big Bang Theory, the CBS sitcom about a group of nerdy friends who know everything about science and geek culture but are clueless about love, was the biggest comedy on TV for many years until it ended in 2019, and its absence is still felt, because there simply isn't any show that hits in the same way on TV right now.
Fortunately, there are many shows, both current and past, that do something similar. They won't make you say "bazinga," but they'll definitely make you laugh.
This list has comedies and light dramas with a will they/won't they like the one between Leonard (Johnny Galecki) and Penny (Kaley Cuoco), a charismatic oddball breakout character like Sheldon (Jim Parsons), an appreciation for the scientific, or some combination.
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