Manchester United have the perfect opportunity to respond to their embarrassing 7-0 defeat against Liverpool at Anfield when the Europa League returns on Thursday.
Former Manchester City manager Manuel Pellegrini brings a fourth different team to Old Trafford for this first leg round of 16 tie and will be looking to pile more misery onto Erik ten Hag's side.
Across spells at City, Villarreal and West Ham United, the veteran coach has won just one of six matches away against United, which was a 3-0 Manchester derby victory in the 2013/14 season.
While Pellegrini knows the northwest well, Betis and United have never previously played each other in a competitive fixture, but the two teams did contest a mid-season friendly during the winter break, which the hosts won 1-0 in Seville.
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