Barcelona maverick is no longer a regular starter under Didier Deschamps but did provide a jolt from the bench for Les Bleus in their taxing 1-1 draw with Hungary on Saturday.
Dembele cracked the post with his first touch but was forced off 30 minutes after coming as he suffered a knee injury and was replaced by Thomas Lemar in the 87th minute.
And now reports in France state he's out for the showdown with Cristiano Ronaldo and Co on Wednesday and that he could also miss the last 16 if the World Cup winners make it.
Deschamps' side know not winning the group could see them face England in the last 16 at Wembley with Gareth Southgate's side still the favourites to come out on top in Group D.
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