Sophia Bush with with her pals, Hilarie Burton and Bethany Joy Lenz, on Wednesday's episode of Good Sam, the freshman medical drama she stars in and executive produces. In the hour, Burton and Lenz play sisters Gretchen and Amy Taylor, respectively, who cross paths with Dr. Sam Griffith (Bush) when Amy is admitted as a patient at Detroit's Lakeshore Sentinel Hospital. The onscreen reunion came about after Bush called up her friends with an idea for them to make guest appearances on the show.