Ole Gunnar Solskjaer has made just one change from the side that beat Brighton 3-2 in a madcap Premier League game last week, with Bailly replacing Victor Lindelof in central defence.
Harry Maguire is fit enough to start alongside Bailly, while Paul Pogba and Nemanja Matic are preferred to Van de Beek, Fred and Scott McTominay in the United midfield to face Tottenham.
Jose Mourinho's Spurs side includes Son Heung-Min, who has been passed fit to play, while new signing Sergio Reguilon starts at left-back.
There is no Gareth Bale in the visitors' squad, but Dele Alli is on the bench. Before the game, Solskjaer stressed the importance of maintaining United's positive results to keep up their challenge at the top end of the league.
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