Gareth Southgate is set to hand the in-from pair their first ever England starts as the Three Lions look to lay down a marker by beating neighbours Wales at Wembley.
The fixture comes before the Nations League clashes against Belgium on Sunday and Denmark on Wednesday, and is set to give some inexperienced names a chance to impress on the hallowed turf.Aston Villa captain Grealish came off the bench against the Danes in the draw between the two sides back in September, with Everton striker Calvert-Lewin yet to play for the senior side.
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